S-Adenosyl-l-ethionine is a Catalytically Competent Analog of S-Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG

Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological radical reactions with the 5’-deoxyadenosyl radical (5’-dAdo•). A [4Fe-4S](+) cluster reductively cleaves SAM to form the Ω organometallic intermediate in which the 5’-deoxyadenosyl moiety is directly bound to the unique iron of the [...

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Publicado en:Angew Chem Int Ed Engl
Main Authors: Impano, Stella, Yang, Hao, Shepard, Eric M., Swimley, Ryan, Pagnier, Adrien, Broderick, William E., Hoffman, Brian M., Broderick, Joan B.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081114/
https://ncbi.nlm.nih.gov/pubmed/33935588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014337
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