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Active-Site Controlled, Jahn–Teller Enabled Regioselectivity in Reductive S–C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes
Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron transfer (ET) from [4Fe–4S](+) to SAM, generating an R(3)S(0) radical that undergoes regioselective homolytic reductive cleavage of the S–C5′ bond to generate the 5′-dAdo· radical. However, cryogenic photo-induced...
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| 發表在: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7934139/ https://ncbi.nlm.nih.gov/pubmed/33372786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10925 |
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