Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes

AIM: Type 1 diabetes (T1D) is a chronic autoimmune disease leading to progressive loss of pancreatic beta cells. Interferon (IFN)-α plays a critical role in the crosstalk between pancreatic beta cells and the immune system in early insulitis. In human beta cells IFNα signals through JAK1 and TYK2, l...

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Bibliografiske detaljer
Udgivet i:Diabetes Obes Metab
Main Authors: de Brachène, Alexandra Coomans, Castela, Angela, de Beeck, Anne Op, Mirmira, Raghavendra G., Marselli, Lorella, Marchetti, Piero, Masse, Craig, Miao, Wenyan, Leit, Silvana, Evans-Molina, Carmella, Eizirik, Decio L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080968/
https://ncbi.nlm.nih.gov/pubmed/32476252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.14104
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