MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers

Sirt6 is involved in multiple biological processes, including aging, metabolism, and tumor suppression. Sirt1, another member of the sirtuin family, functionally overlaps with Sirt6, but its role in tumorigenesis is controversial. In this study, we focused on cell death in association with Sirt6/Sir...

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Vydáno v:Exp Mol Med
Hlavní autoři: Park, Jung Je, Hah, Young-Sool, Ryu, Somi, Cheon, So Young, Won, Seong Jun, Lee, Jong Sil, Hwa, Jeong Seok, Seo, Ji Hyun, Chang, Hyo Won, Kim, Seong Who, Kim, Sang Yoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080835/
https://ncbi.nlm.nih.gov/pubmed/33727672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00578-y
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