Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation

OBJECTIVE: SIRT1 modulates the acetylation of the p65 subunit of nuclear factor-κB (NF-κB) and plays a pivotal role in the inflammatory response. This study sought to assess the role of SIRT1 in rheumatoid arthritis (RA) using a myeloid cell-specific SIRT1 knockout (mSIRT1 KO) mouse. METHODS: mSIRT1...

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Hoofdauteurs: Hah, Young-Sool, Cheon, Yun-Hong, Lim, Hye Song, Cho, Hee Young, Park, Byung-Hyun, Ka, Sun-O, Lee, Young-Rae, Jeong, Dong-Won, Kim, Hyun-Ok, Han, Myung-Kwan, Lee, Sang-Il
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912001/
https://ncbi.nlm.nih.gov/pubmed/24498364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087733
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