Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice

Sirtuin 1 (SIRT1) is a mammalian NAD(+)-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation contributes to i...

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Vydáno v:Korean J Physiol Pharmacol
Hlavní autoři: Kim, Kyung Eun, Kim, Hwajin, Heo, Rok Won, Shin, Hyun Joo, Yi, Chin-ok, Lee, Dong Hoon, Kim, Hyun Joon, Kang, Sang Soo, Cho, Gyeong Jae, Choi, Wan Sung, Roh, Gu Seob
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Physiological Society and The Korean Society of Pharmacology 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553405/
https://ncbi.nlm.nih.gov/pubmed/26330758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2015.19.5.451
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