Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid tumors has proven challenging, in large part because of the lack of tumor-specific targets to direct CAR binding. Tumor selectivity is crucial because on-target, off-tumor activation of CAR T cells can result...

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Détails bibliographiques
Publié dans:Cell Rep Med
Auteurs principaux: Kosti, Paris, Opzoomer, James W., Larios-Martinez, Karen I., Henley-Smith, Rhonda, Scudamore, Cheryl L., Okesola, Mary, Taher, Mustafa Y.M., Davies, David M., Muliaditan, Tamara, Larcombe-Young, Daniel, Woodman, Natalie, Gillett, Cheryl E., Thavaraj, Selvam, Maher, John, Arnold, James N.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
Sujets:
Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080111/
https://ncbi.nlm.nih.gov/pubmed/33948568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100227
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