Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Chimeric antigen receptor (CAR) T-cell therapy entails the genetic engineering of a patient’s T-cells to express membrane spanning fusion receptors with defined specificities for tumor-associated antigens. These CARs are capable of eliciting robust T-cell activation to initiate killing of the target...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Kosti, Paris, Maher, John, Arnold, James N.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972325/
https://ncbi.nlm.nih.gov/pubmed/29872437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01104
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