Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation

B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic tail-anchor enabling them to translocate to their target membrane and to shift into an active conformation where they inhibit pro-apoptotic Bcl-2 proteins to ens...

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Udgivet i:Commun Biol
Main Authors: Mushtaq, Ameeq Ul, Ådén, Jörgen, Clifton, Luke A., Wacklin-Knecht, Hanna, Campana, Mario, Dingeldein, Artur P. G., Persson, Cecilia, Sparrman, Tobias, Gröbner, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079415/
https://ncbi.nlm.nih.gov/pubmed/33907308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02032-1
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