The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry

We have characterized and compared the structures of ergosterol- and cholesterol-containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes before and after interaction with the amphiphilic antifungal drug amphotericin B (AmB) using neutron reflection. AmB inserts into both pure PO...

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Bibliographic Details
Published in:Nanomaterials (Basel)
Main Authors: Delhom, Robin, Nelson, Andrew, Laux, Valerie, Haertlein, Michael, Knecht, Wolfgang, Fragneto, Giovanna, Wacklin-Knecht, Hanna P.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762259/
https://ncbi.nlm.nih.gov/pubmed/33291326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano10122439
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