TGF-β-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity

Transforming growth factor-β (TGF-β) signaling promotes cancer progression. In particular, the epithelial–mesenchymal transition (EMT) induced by TGF-β is considered crucial to the malignant phenotype of cancer cells. Here, we report that the EMT-associated cellular responses induced by TGF-β are me...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Motizuki, Mitsuyoshi, Koinuma, Daizo, Yokoyama, Takashi, Itoh, Yuka, Omata, Chiho, Miyazono, Kohei, Saitoh, Masao, Miyazawa, Keiji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079281/
https://ncbi.nlm.nih.gov/pubmed/33741342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100545
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