Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro

CONTEXT: Dacomitinib and poziotinib, irreversible ErbB family blockers, are often used for treatment of non-small cell lung cancer (NSCLC) in the clinic. OBJECTIVE: This study investigates the effect of dacomitinib on the pharmacokinetics of poziotinib in rats. MATERIALS AND METHODS: Twelve Sprague–...

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Publicado en:Pharm Biol
Autores principales: Ji, Weiping, Shen, Jiquan, Wang, Bo, Chen, Feifei, Meng, Deru, Wang, Shuanghu, Dai, Dapeng, Zhou, Yunfang, Wang, Changxiong, Zhou, Quan
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079061/
https://ncbi.nlm.nih.gov/pubmed/33899675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13880209.2021.1914114
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