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Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux
AKT/PKB is downregulated by the ubiquitin-proteasome system (UPS), which plays a key role in cell survival and tumor progression in various types of cancer. The objective of this study was to determine the relationship between the sequential ubiquitination of lysine residues K284 to K214 in AKT and...
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| Publicado no: | Autophagy |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8078769/ https://ncbi.nlm.nih.gov/pubmed/32164484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1740529 |
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