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HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer
HSPA5/GRP78/BiP plays an important role in cell survival or tumor progression. For these reasons, HSPA5 is an emerging therapeutic target in cancer development. Here we report that HSPA5 contributes to head and neck cancer (HNC) survival via maintenance of lysosomal activity; however, a nonthermal p...
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| Pubblicato in: | Autophagy |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915028/ https://ncbi.nlm.nih.gov/pubmed/29260979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1414126 |
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