Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells

P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) modulate the distribution of drugs and toxins across the blood-brain barrier (BBB). Animal studies reported that infection-induced disruption of these transporters in the developing BBB impairs fetal brain protection. Howe...

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Vydáno v:Tissue Barriers
Hlavní autoři: Eustaquio Do Imperio, Guinever, Lye, Phetcharawan, Bloise, Enrrico, Matthews, Stephen G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8078541/
https://ncbi.nlm.nih.gov/pubmed/33427563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21688370.2020.1860616
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