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Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta

The placental multidrug transporters, P‐glycoprotein (P‐gp, encoded by ABCB1) and breast cancer resistance protein (BCRP,ABCG2) protect the foetus from exposure to maternally derived glucocorticoids, toxins and xenobiotics. During pregnancy, maternal glucocorticoid levels can be elevated by stress o...

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Bibliografski detalji
Izdano u:J Cell Mol Med
Glavni autori: Lye, Phetcharawan, Bloise, Enrrico, Nadeem, Lubna, Gibb, William, Lye, Stephen J., Matthews, Stephen G.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010777/
https://ncbi.nlm.nih.gov/pubmed/29691980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13646
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