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Selective axonal translation of the mRNA isoform encoding prenylated Cdc42 supports axon growth

The small Rho-family GTPase Cdc42 has long been known to have a role in cell motility and axon growth. The eukaryotic Ccd42 gene is alternatively spliced to generate mRNAs with two different 3′ untranslated regions (UTRs) that encode proteins with distinct C-termini. The C-termini of these Cdc42 pro...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Lee, Seung Joon, Zdradzinski, Matthew D., Sahoo, Pabitra K., Kar, Amar N., Patel, Priyanka, Kawaguchi, Riki, Aguilar, Byron J., Lantz, Kelsey D., McCain, Caylee R., Coppola, Giovanni, Lu, Qun, Twiss, Jeffery L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8077440/
https://ncbi.nlm.nih.gov/pubmed/33674450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.251967
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