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The impact of identity by descent on fitness and disease in dogs

Domestic dogs have experienced population bottlenecks, recent inbreeding, and strong artificial selection. These processes have simplified the genetic architecture of complex traits, allowed deleterious variation to persist, and increased both identity-by-descent (IBD) segments and runs of homozygos...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mooney, Jazlyn A., Yohannes, Abigail, Lohmueller, Kirk E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072400/
https://ncbi.nlm.nih.gov/pubmed/33853941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019116118
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