Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to irreversible vision loss. Dysfunction of trabecular meshwork (TM) tissue, a major regulator of aqueous humor (AH) outflow resistance, is associated with intraocular pressure (IOP) elevation in POAG. However, the und...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Patel, Pinkal D., Chen, Yen-Lin, Kasetti, Ramesh B., Maddineni, Prabhavathi, Mayhew, William, Millar, J. Cameron, Ellis, Dorette Z., Sonkusare, Swapnil K., Zode, Gulab S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072326/
https://ncbi.nlm.nih.gov/pubmed/33853948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022461118
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