Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments

T cell development is restricted to the thymus and is dependent on high levels of Notch signaling induced within the thymic microenvironment. To understand Notch function in thymic restriction, we investigated the basis for target gene selectivity in response to quantitative differences in Notch sig...

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Udgivet i:Stem Cell Reports
Main Authors: Furuyama, Suzanne, Wu, Qian “Vicky”, Varnum-Finney, Barbara, Sandstrom, Richard, Meuleman, Wouter, Stamatoyannopoulos, John A., Bernstein, Irwin D.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072033/
https://ncbi.nlm.nih.gov/pubmed/33770495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.02.017
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