SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

Suppression of type I interferon (IFN) response is one pathological outcome of the infection of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 encode multiple IFN antagonists. In this study, we reported on the IFN antago...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Fung, Sin-Yee, Siu, Kam-Leung, Lin, Huayue, Yeung, Man Lung, Jin, Dong-Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071772/
https://ncbi.nlm.nih.gov/pubmed/33907518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.59943
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