Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation

Infection with human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and tropical spastic paraparesis. Type I interferons (IFNs) are key effectors of the innate antiviral response, and IFN-α combined with the nucleoside reverse transcriptase inhibitor zidovudine...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Yuen, Chun-Kit, Chan, Ching-Ping, Fung, Sin-Yee, Wang, Pei-Hui, Wong, Wan-Man, Tang, Hei-Man Vincent, Yuen, Kit-San, Chan, Chi-Ping, Jin, Dong-Yan, Kok, Kin-Hang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810532/
https://ncbi.nlm.nih.gov/pubmed/26819312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00129-16
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