SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor inducer of type I interferon (IFN). Here, we report that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Immunol
Prif Awduron: Wang, Wenjing, Zhou, Zhuo, Xiao, Xia, Tian, Zhongqin, Dong, Xiaojing, Wang, Conghui, Li, Li, Ren, Lili, Lei, Xiaobo, Xiang, Zichun, Wang, Jianwei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907794/
https://ncbi.nlm.nih.gov/pubmed/33637958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00619-y
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