Impaired Ca(2+) Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells

Guanylate cyclase-activating protein 1 (GCAP1) is involved in the shutdown of the phototransduction cascade by regulating the enzymatic activity of retinal guanylate cyclase via a Ca(2+)/cGMP negative feedback. While the phototransduction-associated role of GCAP1 in the photoreceptor outer segment i...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Marino, Valerio, Dal Cortivo, Giuditta, Maltese, Paolo Enrico, Placidi, Giorgio, De Siena, Elisa, Falsini, Benedetto, Bertelli, Matteo, Dell’Orco, Daniele
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070792/
https://ncbi.nlm.nih.gov/pubmed/33919796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22084030
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