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A Versatile Solid-Phase Approach to the Synthesis of Oligonucleotide Conjugates with Biodegradable Hydrazone Linker

One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids, into the cells is conjugating them with different transport ligands via labile or stable bonds. A convenient solid-phase approach for the synthesis of 5′-conjugates of oligonucleotides with biodegradable pH-se...

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Publicat a:Molecules
Autors principals: Meschaninova, Mariya I., Entelis, Nina S., Chernolovskaya, Elena L., Venyaminova, Alya G.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067880/
https://ncbi.nlm.nih.gov/pubmed/33917095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26082119
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