Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its struct...

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Vydáno v:Biomolecules
Hlavní autoři: Kayushin, Alexey L., Tokunova, Julia A., Fateev, Ilja V., Arnautova, Alexandra O., Berzina, Maria Ya., Paramonov, Alexander S., Lutonina, Olga I., Dorofeeva, Elena V., Antonov, Konstantin V., Esipov, Roman S., Mikhailopulo, Igor A., Miroshnikov, Anatoly I., Konstantinova, Irina D.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067715/
https://ncbi.nlm.nih.gov/pubmed/33917025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040539
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