Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its struct...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules
Main Authors: Kayushin, Alexey L., Tokunova, Julia A., Fateev, Ilja V., Arnautova, Alexandra O., Berzina, Maria Ya., Paramonov, Alexander S., Lutonina, Olga I., Dorofeeva, Elena V., Antonov, Konstantin V., Esipov, Roman S., Mikhailopulo, Igor A., Miroshnikov, Anatoly I., Konstantinova, Irina D.
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067715/
https://ncbi.nlm.nih.gov/pubmed/33917025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040539
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items