Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its struct...

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Publicado no:Biomolecules
Main Authors: Kayushin, Alexey L., Tokunova, Julia A., Fateev, Ilja V., Arnautova, Alexandra O., Berzina, Maria Ya., Paramonov, Alexander S., Lutonina, Olga I., Dorofeeva, Elena V., Antonov, Konstantin V., Esipov, Roman S., Mikhailopulo, Igor A., Miroshnikov, Anatoly I., Konstantinova, Irina D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067715/
https://ncbi.nlm.nih.gov/pubmed/33917025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040539
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