Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite

SIMPLE SUMMARY: Somatic mutations in isocitrate dehydrogenase give rise to the excessive production and accumulation of D-2-hydroxyglutarate in certain malignancies. In addition to this well-described oncometabolite, we discovered a chemically related metabolite, namely 2-hydroxyglutarate-γ-lactone,...

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Publicado no:Cancers (Basel)
Principais autores: Berger, Raffaela S., Wachsmuth, Christian J., Waldhier, Magdalena C., Renner-Sattler, Kathrin, Thomas, Simone, Chaturvedi, Anuhar, Niller, Hans-Helmut, Bumes, Elisabeth, Hau, Peter, Proescholdt, Martin, Gronwald, Wolfram, Heuser, Michael, Kreutz, Marina, Oefner, Peter J., Dettmer, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067704/
https://ncbi.nlm.nih.gov/pubmed/33916994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081756
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