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Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite
SIMPLE SUMMARY: Somatic mutations in isocitrate dehydrogenase give rise to the excessive production and accumulation of D-2-hydroxyglutarate in certain malignancies. In addition to this well-described oncometabolite, we discovered a chemically related metabolite, namely 2-hydroxyglutarate-γ-lactone,...
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| Publicado no: | Cancers (Basel) |
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| Principais autores: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8067704/ https://ncbi.nlm.nih.gov/pubmed/33916994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081756 |
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