D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells

Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiation and activation; however, effects on human myel...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Ugele, Ines, Cárdenas-Conejo, Zugey Elizabeth, Hammon, Kathrin, Wehrstein, Monika, Bruss, Christina, Peter, Katrin, Singer, Katrin, Gottfried, Eva, Boesch, Jakob, Oefner, Peter, Dettmer, Katja, Renner, Kathrin, Kreutz, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6387367/
https://ncbi.nlm.nih.gov/pubmed/30744183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030742
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