Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting

Peroxisomal matrix proteins are transported into peroxisomes in a fully-folded state, but whether multimeric proteins are imported as monomers or oligomers is still disputed. Here, we used alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal 5′-phosphate (PLP)-dependent enzyme, whose d...

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Detalhes bibliográficos
Publicado no:J Pers Med
Main Authors: Dindo, Mirco, Ambrosini, Giulia, Oppici, Elisa, Pey, Angel L., O’Toole, Peter J., Marrison, Joanne L., Morrison, Ian E. G., Butturini, Elena, Grottelli, Silvia, Costantini, Claudio, Cellini, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067440/
https://ncbi.nlm.nih.gov/pubmed/33917320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11040273
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