Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons

Cytoplasmic nucleic acids sensing through cGAS-STING-TBK1 pathway is crucial for the production of antiviral interferons (IFNs). IFN production can also be induced by lipopolysaccharide (LPS) stimulation through Toll-like receptor 4 (TLR4) in appropriate conditions. Of note, both IFN production and...

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Bibliographic Details
Published in:Cells
Main Authors: Tesser, Alessandra, Piperno, Giulia Maria, Pin, Alessia, Piscianz, Elisa, Boz, Valentina, Benvenuti, Federica, Tommasini, Alberto
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067196/
https://ncbi.nlm.nih.gov/pubmed/33916318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040785
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