Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is characterized by loss of the retinal pigment epithelium (RPE). While the disease mechanism remains unclear, prior studies have linked AMD with RPE mitochondrial defects and genetic polymorphisms in the comple...

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Pubblicato in:Cells
Autori principali: Ebeling, Mara C., Geng, Zhaohui, Kapphahn, Rebecca J., Roehrich, Heidi, Montezuma, Sandra R., Dutton, James R., Ferrington, Deborah A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066149/
https://ncbi.nlm.nih.gov/pubmed/33918210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040789
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