Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness among older adults. It has been suggested that mitochondrial defects in the retinal pigment epithelium (RPE) underlies AMD pathology. To test this idea, we developed primary cultures of RPE to ask whether RPE from donors with A...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Ferrington, Deborah A., Ebeling, Mara C., Kapphahn, Rebecca J., Terluk, Marcia R., Fisher, Cody R., Polanco, Jorge R., Roehrich, Heidi, Leary, Michaela M., Geng, Zhaohui, Dutton, James R., Montezuma, Sandra R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466586/
https://ncbi.nlm.nih.gov/pubmed/28600982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.015
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