p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts

Hematopoietic stem cells (HSCs) and their progeny sustain lifetime hematopoiesis. Aging alters HSC function, number, and composition and increases risk of hematological malignancies, but how these changes occur in HSCs remains unclear. Signaling via p38 mitogen-activated kinase (p38MAPK) has been pr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sorimachi, Yuriko, Karigane, Daiki, Ootomo, Yukako, Kobayashi, Hiroshi, Morikawa, Takayuki, Otsu, Kinya, Kubota, Yoshiaki, Okamoto, Shinichiro, Goda, Nobuhito, Takubo, Keiyo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065231/
https://ncbi.nlm.nih.gov/pubmed/33745970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100563
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