Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden

HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our...

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Publicado en:Sci Rep
Main Authors: Zhao, Lue Ping, Papadopoulos, George K., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Geraghty, Daniel E., Lernmark, Åke
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065060/
https://ncbi.nlm.nih.gov/pubmed/33893332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86229-8
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