A non-immunological role for γ-interferon–inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption

The extracellular bone resorbing lacuna of the osteoclast shares many characteristics with the degradative lysosome of antigen-presenting cells. γ-Interferon–inducible lysosomal thiol reductase (GILT) enhances antigen processing within lysosomes through direct reduction of antigen disulfides and mai...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ewanchuk, Benjamin W., Arnold, Corey R., Balce, Dale R., Premnath, Priyatha, Orsetti, Tanis L., Warren, Amy L., Olsen, Alexandra, Krawetz, Roman J., Yates, Robin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064644/
https://ncbi.nlm.nih.gov/pubmed/33893096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd3684
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