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Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)
γ-Interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in antigen-presenting cells. GILT facilitates unfolding of endocytosed antigens in MHC class II-containing compartments by enzymatically reducing disulfide bonds. The enzyme is synthesized as a 35-kDa precursor. Alth...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129439/ https://ncbi.nlm.nih.gov/pubmed/12198183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182430499 |
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