Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)

γ-Interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in antigen-presenting cells. GILT facilitates unfolding of endocytosed antigens in MHC class II-containing compartments by enzymatically reducing disulfide bonds. The enzyme is synthesized as a 35-kDa precursor. Alth...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Phan, Uyen T., Lackman, Rebecca L., Cresswell, Peter
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2002
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12198183/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182430499
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