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Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is essential for health. Cargo initiates phagophore biogenesis, which entails the conjugation of LC3 to phosphatidylethanolamine. Current models suggest that clustered ubiquitin chains on a cargo trigger a cascade fro...
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| Udgivet i: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Association for the Advancement of Science
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8064641/ https://ncbi.nlm.nih.gov/pubmed/33893090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4922 |
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