Wordt geladen...
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy
Autophagy degrades cytoplasmic cargo by its delivery to lysosomes within double membrane autophagosomes. Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12–...
Bewaard in:
| Gepubliceerd in: | J Cell Biol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Rockefeller University Press
2020
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7337497/ https://ncbi.nlm.nih.gov/pubmed/32437499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912098 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|