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A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy
Autophagy degrades cytoplasmic cargo by its delivery to lysosomes within double membrane autophagosomes. Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12–...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7337497/ https://ncbi.nlm.nih.gov/pubmed/32437499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912098 |
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