Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Donor T cells mediate both graft-versus-leukemia (GVL) activity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). Development of methods that preserve GVL activity while preventing GVHD remains a long-sought goal. Tolerogenic anti–interleukin-2 (IL-...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Song, Qingxiao, Wang, Xiaoning, Wu, Xiwei, Qin, Hanjun, Li, Yingfei, Riggs, Arthur D., Martin, Paul J., Chen, Yuan-Zhong, Zeng, Defu
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2021
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063091/
https://ncbi.nlm.nih.gov/pubmed/33511398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006345
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