The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway

BACKGROUND: Ubiquitously eXpressed Transcript isoform 2 (UXT—V2) is a prefoldin-like protein involved in NF-κB signaling, apoptosis, and the androgen and estrogen response. UXT-V2 is a cofactor in the NF-κB transcriptional enhanceosome, and its knockdown inhibits TNF-α -induced NF-κB activation. Fbx...

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Publicado en:Biochim Biophys Acta Gen Subj
Autores principales: Spagnol, Valentine, Oliveira, Caio A.B., Randle, Suzanne J., Passos, Patrícia M.S., Correia, Camila R.S.T.B., Simaroli, Natália B., Oliveira, Joice S., Mevissen, Tycho E.T., Medeiros, Ana Carla, Gomes, Marcelo D., Komander, David, Laman, Heike, Teixeira, Felipe Roberti
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063000/
https://ncbi.nlm.nih.gov/pubmed/33010352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2020.129754
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