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Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress
Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus–oocyte complexes (COCs) to 20 µM (P<0.01) an...
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| Publicado no: | Biosci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8062957/ https://ncbi.nlm.nih.gov/pubmed/33844009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20203091 |
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