Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus–oocyte complexes (COCs) to 20 µM (P<0.01) an...

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Bibliographic Details
Published in:Biosci Rep
Main Authors: Gao, Wei, Jin, Yongxun, Hao, Jindong, Huang, Siyi, Wang, Dongxu, Quan, Fushi, Zhang, Mingjun, Zhang, Jiabao, Ren, Wenzhi, Yu, Xianfeng
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2021
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062957/
https://ncbi.nlm.nih.gov/pubmed/33844009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20203091
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