Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus–oocyte complexes (COCs) to 20 µM (P<0.01) an...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biosci Rep
Egile Nagusiak: Gao, Wei, Jin, Yongxun, Hao, Jindong, Huang, Siyi, Wang, Dongxu, Quan, Fushi, Zhang, Mingjun, Zhang, Jiabao, Ren, Wenzhi, Yu, Xianfeng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Portland Press Ltd. 2021
Gaiak:
Developmental Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062957/
https://ncbi.nlm.nih.gov/pubmed/33844009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20203091
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