Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway

The oncogene c-Jun is activated by Jun N-terminal kinase (JNK). Exosomes are nanometer-sized membrane vesicles released from a variety of cell types, and are essential for cell-to-cell communication. By using specific JNK inhibitor SP600125 or CRISPR/Cas9 to delete c-Jun, we found that exosomes from...

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Библиографические подробности
Опубликовано в: :Front Oncol
Главные авторы: Shao, Chen, Huang, Yingying, Fu, Bingjie, Pan, Shunli, Zhao, Xiaoxia, Zhang, Ning, Wang, Wei, Zhang, Zhe, Qiu, Yuling, Wang, Ran, Jin, Meihua, Kong, Dexin
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Oncology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062808/
https://ncbi.nlm.nih.gov/pubmed/33898323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.663183
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