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Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds
The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. Here, we show that by understanding the regulation of the for biosynthetic gene cluster (BGC), we can rewire the BGC to increase production levels. The for BGC consi...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8062789/ https://ncbi.nlm.nih.gov/pubmed/33440167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.12.011 |
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