Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds

The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. Here, we show that by understanding the regulation of the for biosynthetic gene cluster (BGC), we can rewire the BGC to increase production levels. The for BGC consi...

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Vydáno v:Cell Chem Biol
Hlavní autoři: Devine, Rebecca, McDonald, Hannah P., Qin, Zhiwei, Arnold, Corinne J., Noble, Katie, Chandra, Govind, Wilkinson, Barrie, Hutchings, Matthew I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062789/
https://ncbi.nlm.nih.gov/pubmed/33440167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.12.011
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