Hepatocyte nuclear factor 4α prevents the steatosis-to-NASH progression by regulating p53 and bile acid signaling

Hepatocyte nuclear factor 4α (HNF4α) is highly enriched in the liver, but its role in the progression of liver steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) has not been elucidated. In this study, we investigated the effect of gain or loss of hepatocyte HNF4α function on the development a...

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Pubblicato in:Hepatology
Autori principali: Xu, Yanyong, Zhu, Yingdong, Hu, Shuwei, Xu, Yang, Stroup, Diane, Pan, Xiaoli, Bawa, Fathima Cassim, Chen, Shaoru, Gopoju, Raja, Yin, Liya, Zhang, Yanqiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062586/
https://ncbi.nlm.nih.gov/pubmed/33098092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31604
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