Hepatocyte nuclear factor 4α prevents the steatosis-to-NASH progression by regulating p53 and bile acid signaling

Hepatocyte nuclear factor 4α (HNF4α) is highly enriched in the liver, but its role in the progression of liver steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) has not been elucidated. In this study, we investigated the effect of gain or loss of hepatocyte HNF4α function on the development a...

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Udgivet i:Hepatology
Main Authors: Xu, Yanyong, Zhu, Yingdong, Hu, Shuwei, Xu, Yang, Stroup, Diane, Pan, Xiaoli, Bawa, Fathima Cassim, Chen, Shaoru, Gopoju, Raja, Yin, Liya, Zhang, Yanqiao
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062586/
https://ncbi.nlm.nih.gov/pubmed/33098092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31604
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