Machine learning guided aptamer refinement and discovery

Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high affinity and specificity. They are typically discovered by searching large libraries for sequences with desirable binding properties. These libraries, however, are practically constrained to a fraction of the t...

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Publicado en:Nat Commun
Main Authors: Bashir, Ali, Yang, Qin, Wang, Jinpeng, Hoyer, Stephan, Chou, Wenchuan, McLean, Cory, Davis, Geoff, Gong, Qiang, Armstrong, Zan, Jang, Junghoon, Kang, Hui, Pawlosky, Annalisa, Scott, Alexander, Dahl, George E., Berndl, Marc, Dimon, Michelle, Ferguson, B. Scott
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062585/
https://ncbi.nlm.nih.gov/pubmed/33888692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22555-9
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