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Machine learning guided aptamer refinement and discovery

Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high affinity and specificity. They are typically discovered by searching large libraries for sequences with desirable binding properties. These libraries, however, are practically constrained to a fraction of the t...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Bashir, Ali, Yang, Qin, Wang, Jinpeng, Hoyer, Stephan, Chou, Wenchuan, McLean, Cory, Davis, Geoff, Gong, Qiang, Armstrong, Zan, Jang, Junghoon, Kang, Hui, Pawlosky, Annalisa, Scott, Alexander, Dahl, George E., Berndl, Marc, Dimon, Michelle, Ferguson, B. Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062585/
https://ncbi.nlm.nih.gov/pubmed/33888692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22555-9
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